Succinyl CoA Synthase and Regulation of the Enzyme Essay - 8

Succinyl CoA Synthase and Regulation of the Enzyme - Essay Example The amino corrosive answerable for action is the phosphorylated histidine middle of the road (HIS 246 alpha) which is the buildup liable for dephosphorylation of ATP and another site is suspected to be available in the beta subunit that guarantees proceeded with digestion. It is likewise speculated that there is a nucleotide restricting site at the N-terminal of beta subunit (Harel, 2014). This proposes there are two dynamic destinations which are arranged around 35A separated and that the HIS 246 alpha circle generally moves between them while catalysis is happening. There is likewise GLU 208 alpha on the alpha subunit which collaborates with the dynamic HIS 246 buildup in both the phosphorylated and dephosphorylated chemical (Harel, 2014) As demonstrated over the histidine buildup is the one engaged with dephosphorylation or phosphorylation of ATP or ADP individually. It has been suggested that the procedure includes an agreeable restricting catalysis. Along these lines official of ATP at one site improves catalysis at another reactant site (Schã ¼rmann et al, 2011). Authoritative of ATP happens just within the sight of magnesium particle (Mg++) framing an unpredictable which contains two ATP buildup in addition to 2 phosphoric corrosive deposits. In the event that hatching is done this complex is changed over to another with 4 phosphoric corrosive buildups for each given protein. The complex with 4 phosphoric corrosive deposits is the just one with the capacity to respond with succinate and CoA to give Succinyl CoA complex (Harel, 2014). This intricate at that point discharges phosphoric buildups the same number of as bound succinate. The exchange of this phosphoric buildup from the main dynamic site connects with t he exchange to the subsequent dynamic site supporting the agreeable restricting component. These, in this way, implies both ADP and ATP can both be actuating or hindering relying upon which phase of catalysis they tie to the enzyme(Harel, 2014). These, consequently, bolster the reversibility of the catalysis. After the phosphorylation of the Succinyl-CoA andâ subsequent dephosphorylation, it is discharged and proceeds with the Krebs cycle as succinate.

Remember the Titans Essay Example For Students

Recollect the Titans Essay In view of the genuine story of the occasions that occurred in Alexandria,Virginia in 1971, Remember the Titans delineates the battle of an AfricanAmerican football trainer, Herman Boone, who was employed to manage the T.C. Williams Titans. To the individuals in Alexandria football was everything. In any case, when the neighborhood dark secondary school had to incorporate with anall white school, the very establishment of footballs incredible convention was putto the test. It was during this time Boone got trapped in thecourt-requested joining emergency. Boone was a fruitful African American mentor from North Carolina, whowas chose to lead the Titans to triumph. In any case, what he didnt know thathe was chosen with the expectation that the group would blacklist in his reaction ofaccepting the head training work. Later on in the season he was told if heloss a game that would be the finish of his training vocation with the Titans.

Authentic Assessment Essay Example | Topics and Well Written Essays - 2000 words

Bona fide Assessment - Essay Example Presentation Despite some undeniable accomplishments of the over-decade-long US hostile to fear monger battle, to the extent that al-Qaeda’s psychological militant system and the Taliban have endured overwhelming blows with the loss of many key figures from their senior initiative, most outstandingly Osama receptacle Laden, the fear based oppression †the Islamist radical psychological oppression specifically †is neither vanquished nor destroyed. In addition, following 9/11, there was a flood of psychological militant acts around the world, including such against US military staff and regular folks in Iraq, Afghanistan, Saudi Arabia, and so on.; while the fixed safety efforts, alongside the escalated carefulness of the police, FBI and the insight network in general, forestalled numerous fear based oppressor plots to form into brutality on US domain (Mueller, 2011). Unfortunate events, for example, the shootings at Fort Hood, where 13 individuals were slaughtered and 3 2 injured, purportedly by a radicalized Army therapist, show up pretty much a special case (King and Thompson, 2011). The terrorists’ greater achievement abroad, estimated in sheer number of the two instances of appeared savagery and, lamentably, American residents being killed or harmed, derives that the abroad security endeavors of the US government are impeded by specific insufficiencies. The self-destructive bomb assault on the local location occupied by administration work force of the US army installation in Floola and their families, alongside the assault on the USA’s government office in Libya, which brought about the US Ambassador being slaughtered, is a new token of this excruciating truth. Psychological warfare †Trends, Tactics and Perpetrators As Chasdi (2012) brings up, the Worldwide Incidents Tracking System/WITS/of the US National Counterterrorism Center/NCTC/has recognized certain patterns in the field of fear based oppression, rising up out of wor ldwide, local and national turns of events (p. 67). The figures gave by WITS demonstrate that over 10â 000 psychological militant assaults happened in 2011, which influenced 70 nations worldwide and came about in over 12â 500 passings (National Counterterrorism Center/NCTC/, 2012). While the complete number of assaults has fallen by 12 percent and 29 percent, when contrasted with 2010 and 2007 individually, the primary foci of fear monger exercises remain the districts of South Asia and the Near East; taken together, the two areas experienced just about 66% of the high-setback assaults in 2009 and more than 75 percent of 2011 aggregate (NCTC, 2010; NCTC, 2012). Afghanistan, alongside Iraq and Pakistan, endured the worst part of the announced assaults for the third sequential year, both as far as attacks’ number and following loss of life (NCTC, 2009; NCTC, 2010, NCTC, 2011). The quantity of fear monger assaults in Africa and related fatalities, fundamentally connected with the unrest in Somalia and Democratic Republic of Congo, swayed between an ascent of 140 percent (2 200 fatalities) in 2008, when contrasted with 2007, and a drop of in excess of 30 percent in 2010, as against 2009 †from over 3â 200 fatalities to 2â 131 separately (NCTC, 2009; NCTC, 2011). The expansion of 11.5 percent during 2011, in any case, is chiefly inferable from the Nigeria-based gathering Boko Haram (NCTC, 2012). The circumstance in the Western Hemisphere could be likewise portrayed as factor, to the extent that the quantity of revealed fear based oppressor assaults fell by around 25 percent in 2008 and in this manner rose by 27 percent in 2009; while in 2010, the two assaults and passings declined by

Cover Essay Samples Online

Cover Essay Samples OnlineWhen looking for cover essay samples online, there are plenty of options to choose from. Some sites offer samples that you can just print out and send in, while others provide the opportunity to draw up your own.The first thing you should do is determine what types of examples you will be using. The best way to do this is to look at a few examples of cover letters from popular magazines and newspapers. You may be surprised at what a good example of a cover letter can look like.A popular example is the story of Annie Sullivan. This woman went from being rejected by many jobs to finally landing a job at a New York City-based magazine. She first sent out dozens of resumes. Once she was rejected in every one of them, she then became determined to find out the reason why.She wrote a cover letter based on her accomplishments and skills she learned in school. She used some sample stories and put them in a section with a brief description of her interests and writin g style. The cover letter ultimately caught the attention of a magazine editor and eventually landed her the job.If you do not have a chance to gather some samples, you can always try to find some sample stories online. You will probably find hundreds of examples from magazines and newspapers online. These sample stories should be of great use in helping you to get started with writing a cover letter.Another important part of a cover letter is your resume. The information you provide in your resume should be concise and to the point. For instance, instead of explaining how a certain magazine contacted you to write an article about your expertise, it would be much more professional if you just said that they wanted you to write an article about them.There are thousands of sites that offer cover essay samples. You should take the time to visit them. Cover letter samples online are sure to show you how to craft a unique, impressive cover letter that will get your resume noticed.

General Information On The Fitness Industry Essay

BSBMKG408 Conduct market research Part A: Conduct and report on initial research General information on the fitness industry and fitness industry trends, including the sources you have used to find this information. Fitness industry general information: - The fitness industry is an industry which any person, business or organisations who focuses on exercise, health, and overall maintenance of the body participate in. - Fitness industry includes both profit and non-profit organisations whose aims are to promote healthy lifestyles, fit and strong body. - Governmental bodies and non-profit organisations tend to focus on information while for-profit companies provide specific infrastructures such as gyms, swimming pools, sports fields, massage service, etc. Fitness industry trends: - Organisations both private and public are more active in supporting and promoting fitness activities - Fitness educational programs designed for average public fitness consumers is on the rise. - Advanced technology becomes important part in fitness industry such as equipment and on-demand training video. - Increase in faith-base fitness programs as a social mean for people from the same faith. - Change in ranking of training such as high-intensity training, weight control, and wearable technology, etc. This rise and fall of each particular type mainly is a result of new technology being introduced. Now, wearable is on the rise and taking number one spot in popularity. - Fitness businessesShow MoreRelatedGeneral Information On The Fitness Industry2243 Words   |  9 Pagesinitial research General information on the fitness industry and fitness industry trends, including the sources you have used to find this information. Fitness industry general information: It is concerned with the fitness side of business Equipment, space and training are the main focus areas that are done in exchange for a membership fees Gyms are distinguished through the size of the gym or training specialties that are developed for a niche market within the fitness industry The other traditionalRead MoreGeneral Information On The Fitness Industry1651 Words   |  7 Pagesct market research Part A: Conduct and report on initial research General information on the fitness industry and fitness industry trends, including the sources you have used to find this information. Fitness industry general information: Businesses in most industries, observed that operates health clubs, fitness centers and fitness and a range of fitness and exercise services. Conversely, the recognition and the introduction of education on the importance of a healthy lifestyle. Will avoid theRead MoreFitness Industry General Information : Gym, Health And Fitness Club1451 Words   |  6 Pages Fitness industry general information: †¢ Gym, Health fitness club †¢ Personal Trainer service †¢ Sauna †¢ Meal and beverage Fitness industry trends: †¢ Yoga studio †¢ Technology system †¢ Clean foods delivery †¢ Mobile health applications Sources you used to find this information: †¢ articles and advertisements: Advertising on internet. Ex, Google searching fitness plan or YouTube searching fitness plan. †¢ clients and suppliers: †¢ Suppliers who can give you a useful information about diet. †¢ Ex, ClientRead MoreMarketing Industry : Target Customer, And Competitor Analysis835 Words   |  4 PagesExecutive Summary  Industry, Target Customer, and Competitor Analysis Key Characteristics of the Industry (Industry size and growth rate) With the epidemic of obesity that is going on here in the United States, fitness and healthier lifestyles has become very popular. Fitness trainers work primarily at fitness and recreational sports centers. About 265,000 people work as fitness trainers and coaches. About, 20,000 teach recreation and fitness studies at the postsecondary level. Most of the revenueRead MoreNew Product: Nike Fitness1525 Words   |  6 PagesNew product: Nike Fitness As more people become more health conscious, expanding to include fitness centers in their campaigns would be a great step for Nike, especially to compete with a fitness-focused company like Reebok. As the number one sport supplier and their relationship with their sponsored athletes, future consumers would definitely try their new products. They currently have the Nike Run Club and the Nike Training Club that both are free at select NIKE Stores in the United States. NikeRead MoreThe Key Market Success Factors For This Industry848 Words   |  4 PagesFitbit will need to focus on continuing to build their user base and establish credibility as a fitness or health expert to lock out new entrants and play with established fitness brands like Nike. The analysts at Moor Insights Strategy have described some of the key market success factors for this industry (2013). Devices must be easy and intuitive to use, comfortable to wear, and reliable. As sensors grow smaller and smaller, the ability to integrate them into wearable devices without impactingRead MoreHistory Of Agency / Organization : Life Time Fitness1366 Words   |  6 PagesAgency/Organization Life Time Fitness was founded in 1990 as a Minnesota corporation under the name FCA. It wasn’t until 1992 that the name Life Time Fitness was registered for use. In July 1992, Bahram Akradi opened the first Life Time Fitness center in Brooklyn, Minnesota, roughly calculating 30,000 square feet in size. In order to open Life Time Fitness, Afraid had to convert all of his assets into cash as well as join up with a group of shareholders. Today, Life Time Fitness has over 140 centers acrossRead MoreBosu Trainer Case Study Essays1311 Words   |  6 PagesSTUDY Class: ITM 200- Business Information Systems Assignment: Case Study 1 (Chapter 3) Subject: Business Process Management Company: Bosu Fitness Industry: Exercise Equipment Industry Author: Date: Overview The Bosu balance trainer was invented in 1999 by David Wreck the name Bosu means â€Å"Both Sides Utilized† because this exercise equipment has two sides. The two sides of the exercise equipment can be used for training with any kind of work out fitness. Bosu reflects a philosophy inRead MoreSample Resume : Snap Fitness1680 Words   |  7 Pagesfastest growing businesses in the United States is the health industry. Business owners are investing and purchasing fitness franchises that offer low-cost membership as well as convenient hours. Snap Fitness is one of those franchises that have over 1,400 locations worldwide. One of the reasons that Snap Fitness would be beneficial to invest in and also to purchase is because it is a growing industry. â€Å"Economically, the health club industry has proven to be recession-proof, as health-minded consumersRead MoreBusiness Pl Mr. Fit Life1457 Words   |  6 Pageswill serve as the business plan for the men’s retail fitness ap parel store â€Å"Mr. Fit Life†. The paper will cover the vision, mission, and strategy for this start-up business and delve into items such as: marketing strategy, company logistics, and financial planning. The objective of the business plan is to provide sufficient data to have the business considered for funding and mitigate assessed risk. Executive Summary The global sports and fitness clothing market is expected to soon reach over $125

Drug Dependency Essay - 1313 Words

What is dependency? The dictionary definition of dependency is â€Å"The state of relying on or being controlled by someone or something else.† Meaning that drug dependency is when a person relies on a drug to function normally. The same may happen with alcohol. Recent research has shown that drug and alcohol dependency has been steadily increasing. Most theorize that it is the result of stress and peer pressure. However, there have been many ideas concocted to help those addicted handle their situation. For as long as people can remember, human beings have always used drugs and consumed alcohol. From the Indians huddling around a fire and smoking the peace pipe, to the Irish drinking whiskey to their heart’s content, drugs and alcohol have†¦show more content†¦In society today there are many things that can cause stress. From one’s job to their children and even just driving to work. Todays society demands everything to be quick and efficient putting la rge amounts of stress on any normal human being. Poverty may also play a major role in the sudden increase in alcohol and drug dependency. With today’s economy spiraling downwards and men and women being laid off. They may look for something to relieve the stress of their life and turn to substance abuse. Also, instead of being laid off, one’s work itself can cause enormous amounts of stress. For example, if one was a lawyer the stress of a certain case maybe immense. One could be the sole reason a man or woman goes to jail for the rest of his or her life. That much stress could drive anyone to start abusing drugs and or alcohol. The amount of stress that society puts on people today is suspected to be one of the leading causes for this increase in drug and alcohol abuse. The abuse of these substances has steadily increased as our economy declined. Meaning that the harder the times are getting and more difficult it is to make money, more and more people are turning towards drugs to help relieve them of that stress and to comfort them. Adolescence and teenagers are the largest majority of drugShow MoreRelatedDrug Dependency And Drug Related Crime6861 Words   |  28 PagesExecutive Summary Efforts to decrease drug dependency and drug-related crime in the United States have had the opposite effect, introducing increasing levels of crime and drug use within its population. The war on drugs has been lost as more drugs continue to be smuggled across the borders, increasing number of people are using drugs illegally, and violence in the streets continues to climb. A number of arguments have been made in favor of legalizing some less harmful drugs, such as marijuana, as a meansRead MoreDrug Cartel s Economic Dependency On U.s.1964 Words   |  8 Pagesblood oozing out of a rogue head that had been rolled across the alleyway. Taste. The irony tar like saliva laced with blood as you wait for the masked man to steal all sense from your body (Beith n. pag.). With the increasing influence of Mexican drug cartels, all impoverished citizens become subject to violent hate crimes against the government. The government s lack of control over their people, criminal justice system, an d economics demonstrates the instability plaguing Mexican borders. TheRead MoreHow Social Inequalities Affect A Person? S Experience Of Drug And Alcohol Dependency And Their Potential For Recovery1928 Words   |  8 PagesThe aim of this essay is to look at how social inequalities affect a person`s experience of drug and alcohol dependency and their potential for recovery or successful treatment. Due to social inequality people are ostracised from society, these individuals who are stigmatised and suffer discrimination are often the poor as opposed to the hierarchy who have better opportunities in life. Social Inequality refers to the way individuals in society are labelled regarding their status. This could be theirRead MoreCVS STRUCTURE2170 Words   |  9 Pagesstay the nation’s premier integrated pharmacy services provider. One example of CSV growing and changing is adding a new feature to their mobile app. CVS adder a new drug interaction checker as part of its top-rate d CVS Mobile app. This is an industry first. This feature allows customers to quickly and easily check for potential drug interactions by comparing over-the-counter (OTC) products with their prescriptions and other OTCs on their smartphones. CVS would fall under a dynamic environment. EnvironmentalRead MoreFreedom of Drugs â€Å"We have found grassy solitude right here on the riverfront – our own meadow,700 Words   |  3 PagesFreedom of Drugs â€Å"We have found grassy solitude right here on the riverfront – our own meadow, boxed in by concrete. It’s small, but on psychedelics your interpretation is everything. Everything looks pixelated, glowing red and blue with whispers of green. If this were a television, the reception would be clear. The level of detail is overwhelming. From the smallest patch of grass I can take in the whole of human civilization, the planet, the whole damn universe (Grapples par. 3,2)† ThroughoutRead MoreThe Drawbacks Of Anabolic Steroids1384 Words   |  6 Pagesissues have arisen like health problems relating to these drugs have stirred studies like that â€Å"Eighty-three percent of steroid users in a study had a low pumping capacity that was linked to increased risk of heart failure and sudden cardiac death†(Science Daily). More studies have concluded that some â€Å"Common side effects of steroids are mood swings, manic behavior, insomnia, irritability, and lack of good judgement†(Psychcentral). These drugs have been abused by many people and should remain illegalRead MoreNutritious Lunches : Nutritious Meals1375 Words   |  6 Pagesmandated drug tests for the participants. According to Metsch Pollack (2007) â€Å"Approximately 20% of TANF recipients report having used an illicit drug at least once in the past year.† Also, â€Å"Substance abuse is associated with increased duration of TANF receipt.† Participants who are enroll ed in any public assistance programs should not be able to proceed if they are using illicit drugs. Using illicit drugs while receiving benefits should not be allowed. If participants are using drugs they willRead MoreWhen Treatment Becomes Addiction By Faith Kaltenbach Essay868 Words   |  4 Pageson Digg Share this article on Reddit Share this article on Pinterest Expert Author Faith Kaltenbach Those addicted to prescription medications may be prescribed another medication to help overcome dependency. Suboxone is one such medication that can be beneficial for those who are attempting to lead a drug free life. Many are not aware that Suboxone is a narcotic and can be habit forming as well. Addiction to this medication is gradual and many do not recognize a problem until it is too late. AddictionRead MoreModels in the Substance Abuse Field 1206 Words   |  5 Pagesdeportment or motor function,† (DSM-IV, 4th edition) whether it is legal or illegal. Substance abuse refers to the utilization of a drug or other substances for non-medical purposes with the aim of engendering a mind-altering effect in the utilizer (MOH, 2005). It involves the utilization of illegal substances such as cannabis, misuse of licit drugs or utilization of a drug or substances for purposes other than that prescription (MOH, 2005; Rehm Eschmann, 2002). Substance abuse is one of the expeditiousRead MoreEssay about Correlation Between Drug Use and Suicide717 Words   |  3 PagesCorrelation Between Drug Use and Suicide   Ã‚  Ã‚  Ã‚  Ã‚  Americas on-going drug abuse epidemic continues into this millenium, and there are many social problems linked to drug use, including suicide. The disparity of daily life in suburbs or the inner cities are why many people have fallen into their reliance on drugs, including alcohol. Patros and Shamoo (1989) describe the abuse of drugs and alcohol as a slow form of suicide. But many drug abusers choose to end their life before drugs have time to claim

Contract and Procurement Management

Question: Discuss about theContract and Procurement Management. Answer: Introduction Central Queensland University, hereinafter referred to as the Employer, invites sealed tenders from contractors for following contract to be funded entirely by the employer from internal sources for the construction of its new Science and Technology Department building situated in the universitys Brisbane Campus at 160 Ann St, Brisbane City QLD 400. Tenders are invited for contractors to undertake Designing and Construction of the new school building including procurement of material, deployment of labour and completing the construction within the stipulated time mentioned in the Tender Contract Document (TCD). Firms and joint venture companies which have already been pre-qualified by the employer are eligible to submit a tender for this proposed contract. Tendering for this contract is to be financed from the internal sources of the employer and the tendering process is open to individuals, firms and consortiums from any country. To be qualified for the award of this contract, all tenderers are required to satisfy the minimum criteria specified in Section of the Instructions to Tenderers (ITT). Tender documents can be obtained from the office of the Representative at the address given below upon paying a non-refundable fee of $50 or its equivalent if paid in a convertible currency. Upon confirmation of the appropriate evidence of the non-refundable fee amount, the undernoted Representative of the employer will dispatched the relevant Tender Contract Documents along with the Instructions to Tenderers (ITT) by courier, however, the employer does not take any liability for the loss or late delivery of the courier. If requested, the above mentioned documents can be arranged to be transferred electronically after the prospective tenderer submits valid proof of having paid the non-refundable fee. However, the tenderer is required to submit a hard copy of the completed TDC with the representative on or before the last date of submission. All tenders are required to be submitted along with a tender security amount of 5% of the value of the contract as stated in paragraph 19.1 of the Instructions to Tenderers (ITT). Tenders must be submitted by hand at the office of the representative at the address given below on or before 6:00 PM of 23 October 2016 at which time the same shall be opened in the presence of the tenderers or their representatives. A register of the tenderers who purchased the tender documents can be inspected at the address below. Prospective tenderers can obtain any further information, inspect and acquire the tender documents directly at the following office: Mr. Antonio Da Costa Cruz (The CQU Representative) Level 5, Building CQU, 160 Ann St, Brisbane City QLD 400. Email: tender@cqu.com.au Phone Number: 17 3032 5454 Date: 7 September 2016 Project Justification and Contract Process The Tender Document consist of three parts, Parts 1, 2, and 3. These include all of the Sections which are listed below and the tenderer should read them in conjunction with any Addenda issued as per ITT 8, say Baum Baum, (2015). Tendering Procedures Section I: Instruction to Tenderers (ITT) Section II: Tender Data Sheet (TDS) Section III: Evaluation and Qualification Criteria Section IV: Tender Forms Section V: Eligible Countries Requirements Section VI: Requirements Contract Section VII: General Conditions of Contract (GCC) Section VIII: Particular Conditions of Contract (PCC) Section IX: Contract Forms The Invitation for Tenders is issued separately by the Employer and does not form part of the Tender Document. Financing of the Project Any advance payments released to the successful tenderer shall be guaranteed by a reputed bank or financial institution and shall be furnished in the form annexed to the Particular Conditions or as specified by the Employer in another approved format, as per Baum Baum, (2015). The certified amount shown in each Interim Payment Certificate shall be ratified within 56 days after the successful tenderer receives the Statement. During the time when a loan from the Bank from which a part of the payment to the Contractor has been made has been suspended by the bank, the amounts so shown in any statement submitted by the Contractor containing any discrepancy shall be rectified within 14 days after submission of such a statement is made, in the next payment to be made to the Contractor, states Hinkel, (2010). Any undisputed amount certified in the Final Payment Certificate should be notified to the Employer within 56 days after the Payment Certificate is issued, assert Sexton Bogusz, (2013). Project Conditions, Team and Processes In accordance with Section III of ITT, the Evaluation and Qualification Criteria establishes the qualifications for the tenderer to perform the contract as per the information provided in Section IV of the Tender Forms. In case such an eventuality is required under the TDS, the tenderer shall also submit the Manufacturers Authorisation by using the form available in Section IV of the Tender Forms in cases where the tenderer is not the manufacturer or producer of the materials used in the project, confirms King, (2015). Further to this, it may also be required as per the TDS, that the tenderer shall submit authentic evidence that it shall be represented through an Agent in the country, who is fully equipped and capable of carrying out the maintenance, repair and provide adequate spare parts prescribed in the Conditions of Contract and Requirements, in case the tenderer does not conduct direct business in the Employers country. assert Kao, Sung Chen (ed), (2014). Project Labour, Plant, Materials and Sub-contractors All the prices as well as the discounts quoted by the tenderer in the Letter of Tender and the Price Schedules must conform to the requirements specified in ITT 14.2. Unless it is specifically provided in the TDS and the Contract by the tenderer, all the prices quoted shall be considered as fixed. Also, the prices quoted in the Letter of Tender, which are in accordance with ITT 12.1, shall be considered as the total prices of the Tender and shall exclude any discounts which the tenderer may offer later, as per McFarlane, Hopkins Nield, (2012). Requirements for Project Changes Unless there is no other way for such eventualities as a natural calamity, the Contractor will not be permitted an extension of time for circumstances for which the relevant delay has already been taken into account by the Employer, say Sexton Bogusz, (2013). In case, there arises the case of determination of a previous extension of time, then any such Cost will not be paid separately if that has already been taken into account while indexing the inputs to the specific task and its adjustment data in accordance with the cited provisions of Sub-Clause 13.8 (Adjustments for Changes in Cost) as explained by Megarry et al, (2012). Requirements for Quality Assurance and Quality Control If the Employer has determined, on the basis of reasonable evidence available, that the successful tenderer has indulged in any type of prohibited practices, during the time of competing for or while execution of the Contract, the Employer reserves the right, after giving a 14 day notice to the successful tenderer, of terminating the Contract and expel the entire team of the successful tenderer from the Site, as per the applicable provisions of Clause 15 read with Sub-Clause 15.2 of the TDS, as per Davis, (2007). Moreover, if any employee or subcontractor appointed by the successful tenderer is determined on the basis of reasonable evidence, in engaging into prohibited practice during the execution of the contract, then that employee or sub-contractor shall be immediately asked to be removed as per the Sub-Clause 6.9 (Contractors Personnel), says Davis, (2007). For the purpose of this Sub-Clause, the following terms are considered as prohibited practices: Coercive Practice, such as impairing or harming or threatening, directly or indirectly, any party or the property at the site. Collusive Practice, which may be an arrangement between two or more people at the site for achieving an improper purpose. Corrupt Practice means offering, receiving or soliciting, either directly or indirectly, anything of value for influencing the actions of the other party, as suggested by Ashworth Perera, (2015). Fraudulent Practice means acts of omission or commission and may include misrepresentation or attempts to mislead another party for obtaining a financial benefit, as per Ashworth Perera, (2015). Requirements for Document Management and Reporting The tenderer is required to prepare one original copy of the tender documents as described in ITT 11 and mark it ORIGINAL. The tenderer is also required to submit copies of the Tender, as per the number specified in the TDS and mark each of them as COPY. The original as well as the copies of the TDS can be typed or hand written using indelible ink and should be signed by a duly authorised person if signing on behalf of the tenderer. The authorisation should be provided in a written confirmation as specified in the TDS and should be attached to the TDS, suggests Megarry et al, (2012). Requirements for Disputes, Arbitration and Mediation The successful tenderer has to ensure that an appropriate grievance mechanism is made available to all the staff as well as the workers and sub-contractors and this should be used by all the affected persons without fear of intimidation or retaliation, as per Megarry et al, (2012). The successful tenderer must also ensure that all the concerned persons are notified about the grievance mechanism and that this forms an integral part of the training imparted to new employees. Information regarding the same should also be posted at important positions in the relevant areas inside the construction site, assert McFarlane, Hopkins Nield, (2012). It is the duty of the successful tenderer to ensure that the grievance mechanism also involves, at an appropriate level, the management of the company and promptly addresses the concerns of those affected, through the use of an understandable and transparent procedure which also provides feedback to the other concerned persons without any retributi on, as per Ashworth Perera, (2015). Requirements for Safety The successful tenderer is also required to provide the Employer a written Health and Safety Policy for all workers at the site. This should be corroborative with a project-specific Health and Safety Plan as provided by the relevant authority, say Baum Baum, (2015). The Plan should include details of the OHS management system, including plans for managing and monitoring the health and safety risks at the construction site. It is also the duty of the successful tenderer to plan, manage and monitor all the construction work carried out by workers under his control in such a way that it ensures, in a reasonable and practical way, the least risk to the health and safety of the workers, suggest Baum Baum, (2015). List of References Ashworth, A. and Perera, S. 2015, Cost Studies of Buildings, 6th ed. Routledge, Oxon. Baum, A. and Baum, Prof A. 2015, Real Estate Investment: A Strategic Approach, 3rd ed. Routledge, Oxon. Davis, T. 2007, The Real Estate Developer's Handbook: How to Set Up, Operate, and Manage a Financially Successful Real Estate Development. Atlantic Publishing Company, Ocala, FL. Hinkel, Daniel F. 2010, Practical Real Estate Law, 6th ed. Cengage Learning, Boca Raton, FL. Kao, J.C.M., Sung, W. and Chen, R. (ed.). 2014, Green Building, Materials and Civil Engineering. CRC Press, London. King, Sarah. 2015, Beginning Land Law. Routledge, Oxon. McFarlane, Ben, Hopkins, Nicholas and Nield, Sarah. 2012, Land Law: Text, Cases, and Materials. Oxford University Press, Oxford. Megarry, Robert, Wade, William, Harpum, Charles, Bridge, Stuart and Dixon, Martin J. 2012, The Law of Real Property, 8th ed. Sweet Maxwell, New York. Sexton, Roger and Bogusz, Barbara. 2013, Complete Land Law: Text, Cases, and Materials Oxford University Press, Oxford.